Click through to find out more about Tetralysal uses, the side effects of Tetralysal and what our patients thought of the product in our Tetralysal review section. This usually lasts for the first few weeks of use, and can be treated using moisturizer, sunscreen and other skincare products. Retin-A vs. Tretinoin . Objective: The study was designed to compare the efficacy and safety of adapalene gel 0.1% with tretinoin gel 0.025% in the treatment of grade II to III facial acne vulgaris. Adapalene gel 0.1% has efficacy similar to 0.05% isotretinoin, yet with fewer side effects (British Journal of Dermatology). Adapalene, on the other hand, is not as well-studied as an anti-aging treatment and is usually not prescribed frequently as tretinoin to treat the signs of aging. Tretinoin cream vs retinol. Retin-A is a brand that contains the medication tretinoin. The information contained herein is not a substitute for and should never be relied upon for professional medical advice. skin, sweat glands). The most common is an increase in skin sensitivity and dryness, particularly during the first few weeks of treatment. *all photos are models and not actual patients. When using tretinoin it is recommended that you avoid excessive sunlight and always use a sunscreen with a minimum SPF 15+. However, it has several characteristics that make it quite a unique medication when compared to tretinoin. As members of the retinoid family, they're forms of Vitamin A, which has many roles: It's that last role of Vitamin A that retinoids focus on. A total of 297 patients were enrolled by eight investigators in this randomized, investigator-masked study in a parallel group design. Unlimited visits. Our guides to using tretinoin for acne prevention and for anti-aging cover the two most popular uses of this topical retinoid. It is also associated with less irritation than tretinoin. So, you may also see Differin listed as a topical retinoid or a retinoid-like compound as well. ABSM Healthcare Ltd (ZA024585) & Red Label Medical Ltd (ZA030687) is registered with the Information Commissioner's Office to protect your data. adapalene (Differen) tazarotene (Tazorac) tretinoin (Retin-A) Tretinoin is considered to be the most widely used prescription retinoid treatment for wrinkles. On the whole, tretinoin is a safe and effective drug. If you're happy and would like to carry on browsing click 'Accept', or find out more about our This usually resolves itself after a few weeks of consistent use, not unlike the tretinoin “purge” period. First, adapalene can inhibit keratinocyte differentiation, making it helpful for decreasing microcomedone formations, treating inflammation and exfoliating mature comedones. A recent meta-analysis of five well-controlled studies involving more than 900 patients found the efficacy of adapalene 0.1% gel (Differin, Galderma) to be comparable to that of tretinoin 0.025% gel (Retin-A, Valeant). There’s no shortage of acne treatments on the market, and we know it can be overwhelming to look at all the brand names and try to figure out what they actually mean. Tretinoin also has a variety of uncommon side effects that range from skin discoloration to inflammation and even blisters. Long-term studies of tretinoin show similar results, with a low rate of side effects, most of which occur during the first few weeks of treatment and improve over time. And while the side effects of tretinoin can be annoying, the good news is that they typically subside within one to two weeks when managed properly, as your body becomes acclimated to the medication. The Independent Pharmacy, Unit 3 Heston House, 7-9 Emery Road, Brislington, Bristol, BS4 5PF. Adapalene is a newer drug that’s slightly less effective at treating acne than tretinoin. If you’ve started taking tretinoin and experience any of these side effects, it’s best to speak with your healthcare provider immediately. Although the active ingredient in Differin (adapalene) isn't technically a retinoid, it works largely the same way. Tretinoin is a well-researched drug, with comprehensive studies covering everything from its effectiveness as an acne and anti-aging treatment to its potential side effects, long-term benefits and mechanism of action. Of … Head-to-Head. What Is Differin? Connect by text or video with a U.S. board-certified doctor now — wait time is less than 1 minute! by Dr Don Grant (MB ChB DRCOG MRCGP Dip Orth Med) Dr Don Grant is a GP with over 30 years experience and is the Clinical Advisor at The Independent Pharmacy. Irritation, itching, scaling, pain, dryness, skin discolouration or abnormal redness at the site of application. There’s a staggering amount of skincare products designed to help clear the skin off acne, all with varying results. Differin (adapalene) Gel 0.3% is a topical (applied to the skin) medication similar to vitamin A used to treat severe acne in people who are at least 12 years old. Adapalene vs tretinoin acne. My doctor ended up recommending Epiduo, a combination of 2.5% benzoyl peroxide and 0.1% adapalene gel. You will also need to use tretinoin daily for several months to see results. 08515600, VAT No. Because of this, it isn't always the best option. Proactiv vs. Unblemish: What Works Best for Acne? Talk to a doctor now. This study shows show 0.1% adapalene is better tolerate then tretinoin 0.025%. Tretinoin – aka all-trans retinoid acid. Find more information here. Please ensure you always read the information leaflets supplied with any medicinal products.For more information Adapalene vs tretinoin. [8] There are newer stabilized formulations of tretinoin that may not break down when used together with benzoyl peroxide. Get the free app for Members. To make things easier here’s a brief summary of popular treatments you can use: Ultimately, the treatment you should use for your acne will depend not only on the severity and nature of your symptoms but also on how you react to different treatments. Tretinoin and adapalene are two of the most popular, widely used retinoids on the market. In the United States, it’s usually sold under the brand name Differin® and comes in four different forms: lotion (0.1 percent), cream (0.1 percent), solution (0.1 percent) and gel (0.3 percent). It's also known for requiring a purge period, meaning it will often make your acne worse before it starts getting better. When it comes to dealing with acne, retinoids — a class of medications derived from vitamin A — are some of the most effective tools available. Adapalene is a more stable compound that does not break down. Retin-A is a brand name; tretinoin is the name of the active ingredient. Differin, available as a cream or a gel, is a 0.1% formulation of adapalene prescribed for acne sufferers. Accept, {{{ result.pack_size }}} for {{{ result.condition }}}, {{ condition.description | descriptionDisplay }}, Our support team can help via phone 0333 2200 519 or email. There are also a few practical advantages to adapalene: Many adapalene users notice a mild stinging or burning to the skin during this period. The researchers concluded that adapalene 0.3 percent gel was “safe and effective in the long-term” [sic.] Our Tretinoin 101 guide, linked below, lists many of these studies, with plenty of data on how and why tretinoin works as an acne and anti-aging medication. Furthermore, photodegradation of the molecule is less of a concern in comparison to tretinoin and tazarotene. The purpose of this study is to: Evaluate the efficacy of Adapalene gel 0.3% compared to Tretinoin Emollient cream 0.05%, reducing signs of cutaneous photoageing, measured trough photonumeric scale evaluation, investigator evaluation of global response to treatment and subject's evaluation of improvement. We’ll get back to you as soon as we can. The Independent Pharmacy is an online pharmacy and online doctor service is owned and operated by Overall, both tretinoin and adapalene work well to remove and prevent acne. Differin is sold in two forms: Adapalene 0.1% which can be bought without a prescription (over the counter) and Adapalene 0.3% that requires a prescription. COVID-19: Treatments are being dispatched as usual. Like tretinoin, side effects from adapalene are fairly uncommon and usually occur in the first few weeks of treatment. Its main unique offering is … In a review of tretinoin and adapalene, researchers found that tretinoin .05 percent gel “exhibits a greater anti-acne efficacy” than adapalene 0.1 percent gel. In 2016, 85 percent of the people participating … Retin A vs differin. In one study, between 69 percent and 74 percent of patients given adapalene experienced “dramatic reductions” in inflammatory and non-inflammatory acne lesions. Topical tretinoin comes in several different strengths, ranging from .01 percent to .1 percent tretinoin. It’s scientifically proven to reduce acne, fight the signs of aging and improve a variety of factors related to skin health. All in all, tretinoin is an effective, safe medication that produces good results with the potential for few minor common side effects for users. you looking for, please contact our support team on 0333 2200 519 for help and advice. We use website cookies to ensure that you receive the best experience. Adapalene and tretinoin are chemical compounds typically used to relieve acne. Important: This email goes to a third party - never send personal, medical, or health information to this address. Differin (Adapalene) and Epiduo are two gels used for acne treatment. {{{ result._highlightResult.name.value }}}, {{{ condition._highlightResult.name.value }}}, adapalene is less likely to cause further irritation, but tretinoin is more potent, https://www.practiceupdate.com/content/azelaic-acid-vs-adapalene-in-treatment-of-female-adult-acne/19574, https://www.ncbi.nlm.nih.gov/pubmed/25399481, https://www.medicines.org.uk/emc/files/pil.285.pdf, https://www.medicines.org.uk/emc/files/pil.920.pdf, https://www.ncbi.nlm.nih.gov/pubmed/20488582, Charity & Corporate Social Responsibility. What's the evidence? More than 70% of patients in both groups had complete clearance or marked improvement. Everyone has a different skin type and acne can have multiple causes - a treatment that works perfectly for one person might be less effective or cause greater irritation in another. Though it's also aimed at moderate acne, it's certainly a stronger treatment than Differin. Beyond the “purge” and mild side effects, the major disadvantages of tretinoin are its effects on your skin’s sensitivity to sunlight. Cookie Policy. Accordingly, numerous clinical trials have compared adapalene and tretinoin in the management of acne vulgaris and concluded that tretinoin 0.05% gel exhibits a greater anti-acne efficacy than adapalene 0.1% gel, but has higher skin irritation potential. However, it’s best to discuss your options with your healthcare provider to figure out what’s best for you. A 52-week study of adapalene 0.3 percent gel (the higher, prescription-only concentration of topical adapalene) found that only 21 percent of users experienced side effects from the treatment, of which the most common were dry skin, scaling and skin discomfort. Tretinoin and adapalene are both highly effective at treating acne. A 27-year-old female asked: if i don't have acne, but want to use a retinoid for anti-aging properties, which do you recommend? Restrictions apply. Other retinoids are undergoing clinical trials. From an anti-aging perspective, tretinoin is the better choice for most people, with a great track record of reducing wrinkles, hyperpigmentation and other signs of skin aging. (adapalene vs tretinoin vs tazarotene) Dr. Katherine Mcgraw answered. Tretinoin creams and gels can degrade quickly in sunlight, do not use it at the same time as benzoyl peroxide, A 52-week study of adapalene 0.3 percent gel, CCPA: Do Not Sell My Personal Information. Clinical trials have found that 0.1% adapalene works faster than 0.025% tretinoin, the most commonly used retinoid, and with less irritation to boot! Unlike tretinoin, adapalene does not bind to proteins within the cell. It is most effective as a treatment for acne, but can also help with wrinkles and sun damage. The Independent Pharmacy is registered with the CQC (1-1135933317), It's actually the first retinoid to be approved for over-the-counter sale in the US, though it still requires a prescription in the UK. If you have mild or moderate acne, both tretinoin and adapalene are likely to produce a lasting, significant improvement if used consistently. Get to clear skin with the Clear90 app. Like tretinoin, adapalene is a retinoid. Suffering from acne is frustrating enough - you shouldn't have to deal with the further frustration of browsing countless treatments without knowing what makes them different. 19 years experience Pediatrics. Adapalene is particularly good for getting inside pores, preventing clogged pores, plus it has antiinflammatory effects too. Currently, the stronger .03 percent gel is only available with a prescription. Studies show that adapalene is effective at treating acne. Another major disadvantage of tretinoin is that, from a chemical perspective, it’s quite a fragile substance. One (tretinoin) is a prescription-only medication with a usage history covering over half a century. Retinoid, Retinol and Adapalene — Here's the important takeaway: Treclin is more expensive, but it is stronger than Differin and has antibiotic properties. Tretinoin vs Adapalene. Simply press 's' on your keyboard and our quick search tool will appear. Tretinoin Often known by the brand name Retin-A, tretinoin … tretinoin 0.025% gel to adapalene 0.1% solution. Adapalene Vs Tretinoin: Differin, Treclin Gel, and Other Topical Acne Treatments Compared. Unlike the retinoid tretinoin (Retin-A), adapalene has also been shown to retain its efficacy when applied at the same time as benzoyl peroxide due to its more stable chemical structure. The other (Adapalene) is a newer, third-generation retinoid that’s available both as prescription medication and, as of 2016, as an over-the-counter treatment. Studies show that both drugs produce a significant reduction in acne lesions over the long term. Retin-A (tretinoin) Cream and Gel is a form of Vitamin A used for the topical treatment of acne vulgaris. It’s sold over the counter and by prescription and tends to be slightly less irritating to the skin than tretinoin, making it worth considering if you have sensitive, easily-irritated facial skin. This approach can help you get the best results while limiting your risk of experiencing side effects from topical skin medication. Most of adverse events to adapalene and many on tretinoin group were related to skin irritation, dry skin, scaling, pruritus, burning, and postinflammatory hyperpigmentation. There are other topical retinoids — tretinoin and tazarotene — used to treat acne, but adapalene is the only one available over the counter. Not to worry, you've got the medication you're supposed to have. see our policies and terms and conditions at the bottom of every page. However, it has several characteristics that make it quite a unique medication when compared to tretinoin. Adapalene Topical rated 6.5/10 vs Isotretinoin rated 8.0/10 in overall patient satisfaction. Tretinoin is a proven, well established drug that’s been in use for decades. See website for full details and important safety information. Both adapalene and tretinoin produce dramatic reductions in total, inflammatory and non-inflammatory lesion counts, in the range of 69-74% on average. If you are interested in a prescription product, Hims will assist in setting up a visit for you with an independent physician who will evaluate whether or not you are an appropriate candidate for the prescription product and if appropriate, may write you a prescription for the product which you can fill at the pharmacy of your choice. He is a registered pharmacist and the registered manager of our service with the CQC. If you can't find what you are Studies of the two drugs also show that tretinoin typically produces slightly higher levels of skin irritation than adapalene. And Adapalene is the synthetic form of Retin-A. Read more information about this treatment in our 'What is Treclin?' Adapalene has similar acne-fighting and exfoliating properties to tretinoin, but it’s not quite as harsh. Epiduo is a combination of Adapalene 0.1% and Benzoyl Peroxide 2.5%. Overall, tretinoin has become something of an “industry standard” retinoid for good reason — it’s affordable, effective and safe. $10/month. Tretinoin (Retin-A, generic), tazarotene (Avage, Tazorac), and adapalene (Differin) are prescription retinoids. Acne is one of the most common skin conditions in the world. It is not intended for customer support. 176 5700 90) and Red Label Medical Ltd (Company Reg. & MHRA (C42990). You should consult your doctor if you think you may have a health problem or before you start taking a new medicine. Are you interested in using tretinoin to prevent acne and reverse the signs of aging? Here's how they differ: Which is best all comes down to the severity and nature of your acne symptoms - we can assess your case and guide you towards the most suitable treatment.   Yes, even medications have brand names. Regulating epithelial tissue (e.g. Treclin, however, is a medicinal gel containing two active ingredients: a 0.025% concentration of tretinoin, and a 1% concentration of clindamycin (a strong antibiotic). Adapalene is available in several different strengths. In clinical studies, adapalene has shown superior tolerability to other topical prescription retinoids, meaning Differin is gentler on your skin, while still effective. Tretinoin can take several months before delivering noticeable results, so it’s important to understand it’s a process that takes time. skin irritation or tenderness, a burning sensation, dry skin, itching. Tetralysal is the most common oral acne antibiotic to combine with Differin. Dr Don Grant is a GP with over 30 years experience and is the Clinical Advisor at The Independent Pharmacy. ABSM Healthcare Ltd (Company Reg. Tretinoin creams and gels can degrade quickly in sunlight. Despite both drugs being retinoids, only tretinoin has an established record of working as an anti-aging treatment, with countless studies showing a reduction in wrinkles, skin discoloration and other signs of photoaging over the long term. Because of this, it may not be recommended first if your goal is to reduce the visibility of wrinkles, creases or pigmented spots. On paper, both drugs can look almost exactly the same, with similar benefits and potential side effects. On the whole, studies comparing tretinoin and adapalene typically find that tretinoin is slightly more effective as an acne treatment. 08676338). Always talk to your doctor about the risks and benefits of any treatment. After doing some research, I decided that I should see a dermatologist to get a prescription for a topical retinoid such as tretinoin. While Differin is an excellent all-around acne treatment, it might struggle to have an impact on more severe cases. Compare Adapalene Topical vs Isotretinoin head-to-head with other drugs for uses, ratings, cost, side effects and interactions. This means that if you have severe or persistent acne, you may get better results from tretinoin than by using a .1 percent, over-the-counter form of adapalene. Adapalene is better than tretinoin at targeting the causes of acne. Newer stabilized formulations of tretinoin that may not break down when used together benzoyl. Other treatments a brand name for the drug tretinoin properties to tretinoin adapalene. Ingredient in Differin ( adapalene vs tretinoin the drug tretinoin 's why we 've created this,... Certainly a stronger treatment than Differin and has antibiotic properties mild or moderate acne, 's!, both drugs can look almost exactly the same efficacy at the Independent Pharmacy, Unit 3 House! Offers comparable efficacy to tretinoin s quite a unique medication when compared to.! 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Discoloration to inflammation and even blisters online doctor service is owned and operated by ABSM healthcare Ltd Company. Or gel ( for those with acne ) and Red Label medical Ltd ( Company Reg does... Differentiation, making it helpful for decreasing microcomedone formations, treating inflammation and exfoliating mature comedones getting inside,... And which one is best for acne half a century also associated less. Effective and safe than Differin and has antibiotic properties 12-month duration tretinoin may break.... Moderate acne, but appears to be less likely to produce a significant reduction in acne lesions over long.: Differin, available as a topical retinoid and safe but only adapalene is better than tretinoin comparison Differin!